Physiologically based cord clamping for infants ≥32 0 weeks gestation: A randomised clinical trial and reference percentiles for heart rate and oxygen saturation for infants ≥35 0 weeks gestation

S Badurdeen; PG Davis; SB Hooper; S Donath; GA Santomartino; A Heng; D Zannino; M Hoq; CFO Kamlin; SC Kane; A Woodward; CT Roberts; GR Polglase; DA Blank; J Dawson; A Dennis; R Hodges; S Jacobs; AT Pas; A Stewart; M ThioLluch

Journal article

Physiologically based cord clamping for infants ≥32 0 weeks gestation: A randomised clinical trial and reference percentiles for heart rate and oxygen saturation for infants ≥35 0 weeks gestation

S Badurdeen, PG Davis, SB Hooper, S Donath, GA Santomartino, A Heng, D Zannino, M Hoq, CFO Kamlin, SC Kane, A Woodward, CT Roberts, GR Polglase, DA Blank, J Dawson, A Dennis, R Hodges, S Jacobs, AT Pas, A Stewart Show all

Plos Medicine | PUBLIC LIBRARY SCIENCE | Published : 2022

DOI: 10.1371/journal.pmed.1004029

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Abstract

Background Globally, the majority of newborns requiring resuscitation at birth are full term or late-preterm infants. These infants typically have their umbilical cord clamped early (ECC) before moving to a resuscitation platform, losing the potential support of the placental circulation. Physiologically based cord clamping (PBCC) is clamping the umbilical cord after establishing lung aeration and holds promise as a readily available means of improving early newborn outcomes. In mechanically ventilated lambs, PBCC improved cardiovascular stability and reduced hypoxia. We hypothesised that PBCC compared to ECC would result in higher heart rate (HR) in infants needing resuscitation, without co..

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University of Melbourne Researchers

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The study authors receive funding from the National Health and Medical Research Council(NH & MRC,https://www.nhmrc.gov.au/) Program Grant(#606789), Fellowships (SBH:APP545921,GRP:APP1105526,PGD:APP1059111, CTR:APP1175634), Monash University (CTR: Kathleen Tinsley Fellowand DAB: Victor Yu Fellow),and Australian Government Research Training Program Scholarships(SB and SCK).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.